Opportunity Information: Apply for W81XWH 19 PRMRP IIRA
The CDMRP Peer Reviewed Medical Research Program (PRMRP) Investigator-Initiated Research Award (IIRA) is a Department of Defense funding opportunity meant to back investigator-driven medical research projects that can make a meaningful contribution to research and/or patient care for diseases or conditions that fall within at least one of the FY19 PRMRP Topic Areas. The central idea is to give researchers room to propose strong, original studies that are not limited to a narrow preset method, as long as the work is clearly connected to one or more of the designated PRMRP topic areas for that fiscal year.
A key expectation of this award is that the proposed research is built on a clear rationale supported by relevant evidence. That rationale can come from multiple sources, including laboratory findings, population-based or epidemiological observations, a clinician's direct experience treating patients, or other forms of preliminary or anecdotal insight that point to an important scientific or clinical question. Regardless of where the idea originates, the application must include data that justify the approach and demonstrate that the study is grounded in reality. Those supporting data can be unpublished preliminary results generated by the applicant or evidence drawn from the existing published literature, but they need to be clearly relevant to why the proposed study should be done and why it is likely to succeed.
The program places heavy emphasis on impact. The IIRA is positioned to support research that could generate highly impactful results capable of driving critical discoveries or major advances in the field. Applicants are expected to explain, in a straightforward and convincing way, what the project is likely to produce in both the near term and long term. These outcomes can include new knowledge (for example, better understanding of disease mechanisms, risk factors, biomarkers, or treatment responses) and/or materiel products (such as tools, datasets, methods, protocols, or other tangible research-enabling outputs). Just as important, the proposal must connect those anticipated outputs to a central, critical problem in the relevant research or patient-care landscape, showing how the study would move the field forward rather than simply adding incremental information.
Administratively, the opportunity is offered by the Department of Defense, Department of the Army, through the U.S. Army Medical Research Acquisition Activity (USAMRAA), under Funding Opportunity Number W81XWH 19 PRMRP IIRA. The assistance mechanisms listed include both grants and cooperative agreements, reflecting that awards may involve varying degrees of government involvement depending on the specific project. It is categorized under science and technology and other research and development, with CFDA number 12.420. Eligibility is described as unrestricted, meaning it is broadly open to many entity types, subject to any additional eligibility clarifications that may appear in the full announcement. The posting indicates an expected total of 42 awards, with an original closing date of July 11, 2019, and a creation date of January 15, 2019. The listed award ceiling is shown as 0, which typically signals that the maximum award amount is not captured in that summary field and would need to be confirmed in the full funding announcement or associated program guidance.
Overall, this award supports well-justified, investigator-originated biomedical research tied to FY19 PRMRP topic areas, with a strong requirement to show supporting evidence and a clear, credible path to outcomes that could substantially influence research directions and/or improve patient care.Apply for W81XWH 19 PRMRP IIRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "CDMRP Peer Reviewed Medical Research Program Investigator-Initiated Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jan 15, 2019.
- Applicants must submit their applications by Jul 11, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 42 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: CDMRP Peer Reviewed Medical Research Program (PRMRP) Investigator-Initiated Research Award (IIRA)
What is the PRMRP Investigator-Initiated Research Award (IIRA)?
The PRMRP Investigator-Initiated Research Award (IIRA) is a Department of Defense funding opportunity intended to support investigator-driven medical research projects. The goal is to fund strong, original studies that can make a meaningful contribution to research and/or patient care for diseases or conditions that fall within at least one of the FY19 PRMRP Topic Areas.
Who offers this funding opportunity?
This opportunity is offered by the Department of Defense, Department of the Army, through the U.S. Army Medical Research Acquisition Activity (USAMRAA).
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number listed is W81XWH 19 PRMRP IIRA.
What types of funding mechanisms are available under this opportunity?
The assistance mechanisms listed include grants and cooperative agreements. This indicates that awards may be issued either as traditional grants or as cooperative agreements, which can involve varying degrees of government involvement depending on the specific project.
What research topics are eligible?
Projects must address diseases or conditions that fall within at least one of the FY19 PRMRP Topic Areas. The opportunity is designed to be flexible in approach as long as the research is clearly connected to one or more designated topic areas for that fiscal year.
Does the program require a specific research method or design?
No narrow, preset method is required based on the summary provided. The central premise is to give researchers room to propose original, investigator-initiated studies, provided the work is clearly tied to one or more FY19 PRMRP Topic Areas and is well-justified by supporting evidence.
What is meant by "investigator-initiated" research in this context?
"Investigator-initiated" means the core research idea and approach originate from the applicant rather than being constrained to a tightly prescribed government-defined method. Applicants are expected to propose their own research questions and study plans, while ensuring alignment with FY19 PRMRP Topic Areas.
What level of preliminary support or rationale is expected in the application?
A key expectation is that the proposed research is built on a clear rationale supported by relevant evidence. The application must include data that justify the approach and demonstrate that the study is grounded in reality.
What kinds of evidence can be used to support the rationale?
The rationale can be supported by multiple sources, including laboratory findings, population-based or epidemiological observations, a clinician's direct experience treating patients, or other forms of preliminary or anecdotal insight. However, regardless of the origin of the idea, the application must include relevant data to justify the proposed approach.
Do supporting data need to be published?
No. Supporting data can be unpublished preliminary results generated by the applicant or evidence drawn from the existing published literature. In either case, the evidence needs to be clearly relevant to why the proposed study should be done and why it is likely to succeed.
What does the program emphasize most when evaluating the research concept?
The summary emphasizes impact as a central priority. The IIRA is positioned to support research that could generate highly impactful results capable of driving critical discoveries or major advances in the field.
What kinds of outcomes are applicants expected to describe?
Applicants are expected to explain what the project is likely to produce in both the near term and long term. Anticipated outcomes can include new knowledge (such as insights into disease mechanisms, risk factors, biomarkers, or treatment responses) and/or materiel products (such as tools, datasets, methods, protocols, or other tangible research-enabling outputs).
What are "materiel products" in the context of this award?
Based on the description provided, "materiel products" refers to tangible outputs that enable research or translation, including tools, datasets, methods, and protocols, as well as other concrete research-enabling deliverables.
How should an applicant connect project outcomes to real-world needs?
The proposal is expected to connect anticipated outputs to a central, critical problem in the relevant research and/or patient-care landscape. Applicants should show how the study would move the field forward rather than simply adding incremental information.
Is the award intended for incremental advances or major advances?
The program description highlights support for projects that could drive critical discoveries or major advances. Applicants should demonstrate how their project could substantially influence research directions and/or improve patient care, not merely add incremental findings.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 12.420.
How is the opportunity categorized?
It is categorized under science and technology and other research and development.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is broadly open to many entity types, subject to any additional eligibility clarifications that may appear in the full announcement.
How many awards are expected to be made?
The posting indicates an expected total of 42 awards.
What were the key dates for this funding opportunity?
The creation date listed is January 15, 2019, and the original closing date is July 11, 2019.
What is the maximum (ceiling) award amount?
The listed award ceiling is shown as 0 in the summary. This typically indicates the maximum award amount is not captured in that summary field and would need to be confirmed in the full funding announcement or associated program guidance.
Why might the assistance listing include both grants and cooperative agreements?
The summary notes that awards may involve varying degrees of government involvement depending on the specific project. Listing both mechanisms signals that some projects may be administered as grants while others may be administered as cooperative agreements.
What is the core purpose of this award overall?
Overall, the award supports well-justified, investigator-originated biomedical research tied to FY19 PRMRP Topic Areas, with a strong requirement for supporting evidence and a clear, credible path to outcomes that could substantially influence research directions and/or improve patient care.
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