Opportunity Information: Apply for HRSA 25 049
The Ryan White HIV/AIDS Program Part C Capacity Development Program (HRSA-25-049) is a discretionary federal grant opportunity from the Health Resources and Services Administration (HRSA) focused on helping organizations build stronger, more resilient systems for delivering HIV primary health care. The central goal is organizational capacity building, meaning the program is designed to help service providers adapt to a changing health care environment while improving access to high-quality HIV medical care for people who are low-income and underserved. In practical terms, this opportunity is aimed at strengthening the internal abilities of eligible organizations so they can sustain and improve HIV clinical services, respond to evolving policies and care models, and better meet the needs of people with HIV in their communities.
This funding opportunity falls under the Health activity category and is associated with CFDA number 93.918. It is authorized under Section 2652 of the Public Health Service (PHS) Act. HRSA expects to make around 60 awards under this notice of funding opportunity (NOFO). The listing shows an award ceiling of 0, which typically indicates that a specific maximum award amount is not provided in the summary field and applicants should rely on the full NOFO for detailed budget expectations, limits, and any standardized funding amounts or formulas that apply.
Eligibility is limited to domestic organizations and government entities. Eligible applicants include public entities and nonprofit private entities, including community-based organizations, as well as nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education in the categories listed). Government applicants may include state governments, county governments, city or township governments, and special district governments. Native American tribal governments (federally recognized) and Native American tribal organizations are also eligible. The term "domestic" is defined broadly to include the 50 states and the District of Columbia, the Commonwealth of Puerto Rico, the Northern Mariana Islands, American Samoa, Guam, the U.S. Virgin Islands, and the freely associated states and territories listed: the Federated States of Micronesia, the Republic of the Marshall Islands, and the Republic of Palau.
There are clear restrictions on who may not apply. Individuals are not eligible applicants under this NOFO. Foreign entities are not eligible for this award, which means organizations based outside the defined U.S. domestic jurisdictions cannot apply, even if they have partnerships or connections to U.S.-based programs. The opportunity was created on January 16, 2025, and the original application closing date is March 18, 2025.
Overall, the program is best understood as a targeted investment in the operational and service-delivery strength of Ryan White Part C-related HIV primary care providers and similar eligible organizations. The intent is not only to support direct care access for underserved people with HIV, but also to ensure that the organizations providing that care have the systems, staffing capacity, and readiness needed to keep pace with changes in the broader health care landscape while maintaining high-quality HIV clinical services.Apply for HRSA 25 049
- The Health Resources and Services Administration in the health sector is offering a public funding opportunity titled "Ryan White HIV/AIDS Program Part C Capacity Development Program" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.918.
- This funding opportunity was created on 2025-01-16.
- Applicants must submit their applications by 2025-03-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 60 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Others.
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FAQs: Ryan White HIV/AIDS Program Part C Capacity Development Program (HRSA-25-049)
What is the Ryan White HIV/AIDS Program Part C Capacity Development Program (HRSA-25-049)?
It is a discretionary federal grant opportunity from the Health Resources and Services Administration (HRSA) focused on organizational capacity building for HIV primary health care providers. The purpose is to help eligible organizations strengthen their internal systems and operational readiness so they can sustain and improve high-quality HIV clinical services, especially for people who are low-income and underserved.
What is the main goal of this funding opportunity?
The central goal is organizational capacity building. This means the funding is intended to improve the ability of service providers to adapt to a changing health care environment, respond to evolving policies and care models, and strengthen systems that support ongoing delivery of HIV primary medical care.
What type of activities is this program designed to support?
Based on the description provided, the program supports activities that build stronger, more resilient systems for delivering HIV primary health care. The emphasis is on strengthening internal organizational abilities (systems, staffing capacity, and readiness) to sustain and improve HIV clinical services and maintain high-quality care as the broader health care landscape changes.
Who is this opportunity intended to help?
The opportunity is designed to benefit people with HIV who are low-income and underserved by improving the strength and stability of the organizations that provide HIV primary medical care in their communities.
What is the activity category for this grant?
This funding opportunity falls under the Health activity category.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.918.
What is the legal authority for this program?
It is authorized under Section 2652 of the Public Health Service (PHS) Act.
How many awards does HRSA expect to make?
HRSA expects to make around 60 awards under this Notice of Funding Opportunity (NOFO).
Is there a maximum award amount (award ceiling)?
The listing shows an award ceiling of 0. This typically means a specific maximum award amount is not provided in the summary field, and applicants should rely on the full NOFO for budget expectations, limits, and any standardized funding amounts or formulas that may apply.
Who is eligible to apply?
Eligibility is limited to domestic organizations and government entities. Eligible applicants include public entities and nonprofit private entities (including community-based organizations), as well as nonprofits with or without 501(c)(3) status (so long as they are not institutions of higher education in the categories listed in the eligibility limitations). Government applicants may include state governments, county governments, city or township governments, and special district governments. Federally recognized Native American tribal governments and Native American tribal organizations are also eligible.
Can a nonprofit apply if it does not have 501(c)(3) status?
Yes. The eligibility description includes nonprofits with or without 501(c)(3) status, as long as they are not institutions of higher education in the categories listed as excluded.
Are community-based organizations eligible?
Yes. Community-based organizations are included under eligible nonprofit private entities.
Which government entities are eligible to apply?
Eligible government applicants may include state governments, county governments, city or township governments, and special district governments.
Are Native American tribes and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments and Native American tribal organizations are eligible.
What does "domestic" mean for eligibility purposes?
Domestic is defined to include the 50 states and the District of Columbia, the Commonwealth of Puerto Rico, the Northern Mariana Islands, American Samoa, Guam, the U.S. Virgin Islands, and the freely associated states and territories listed: the Federated States of Micronesia, the Republic of the Marshall Islands, and the Republic of Palau.
Are individuals allowed to apply?
No. Individuals are not eligible applicants under this NOFO.
Are foreign entities eligible to apply?
No. Foreign entities are not eligible for this award. Organizations based outside the defined U.S. domestic jurisdictions cannot apply, even if they have partnerships or connections to U.S.-based programs.
What is the funding opportunity number (NOFO number)?
The NOFO number is HRSA-25-049.
When was this opportunity created?
The opportunity was created on January 16, 2025.
What is the application closing date?
The original application closing date is March 18, 2025.
Is this program focused on direct patient care or organizational improvements?
The description emphasizes organizational improvements (capacity development) to strengthen systems and internal capabilities that support delivery of HIV primary health care. While the intent includes improving access to high-quality HIV medical care for low-income and underserved people with HIV, the central focus is building the service-delivery and operational strength of eligible organizations.
What kinds of outcomes is this program trying to achieve?
The stated intent is to help organizations sustain and improve HIV clinical services, stay responsive to changing policies and care models, and maintain high-quality HIV primary medical care for underserved communities by building stronger organizational systems, staffing capacity, and readiness.
How should applicants interpret the award ceiling being listed as 0?
The summary indicates that an award ceiling value of 0 typically means the maximum award amount is not specified in the listing summary. Applicants should refer to the full NOFO for any budget expectations, limits, or standardized funding amounts or formulas.
Is this a discretionary grant?
Yes. The opportunity is described as a discretionary federal grant opportunity from HRSA.
What makes this program different from general service expansion funding?
Based on the description provided, the distinguishing feature is the focus on capacity development and organizational resilience. The funding is positioned as a targeted investment in strengthening internal systems and readiness so organizations can keep pace with changes in the health care environment while continuing to provide high-quality HIV clinical services.
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| Addressing Stigma to End the HIV Epidemic in the U.S. Apply for HRSA 25 060 Funding Number: HRSA 25 060 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Improving Mental Health and Engagement in Care Among People with HIV — Evaluation Provider Apply for HRSA 25 059 Funding Number: HRSA 25 059 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Ryan White HIV/AIDS Program (RWHAP) Web-Based Platform for HIV Tools and Resources Apply for HRSA 25 062 Funding Number: HRSA 25 062 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Street Medicine Interventions for People with HIV who are Unsheltered - Demonstration Sites Apply for HRSA 25 056 Funding Number: HRSA 25 056 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Street Medicine Interventions for People with HIV who are Unsheltered – Capacity Builder Provider (HRSA-25-055) and Street Medicine Interventions for People with HIV who are Unsheltered – Evaluation Provider (HRSA-25-057) Apply for HRSA 25 055 Funding Number: HRSA 25 055 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Improving Mental Health and Engagement in Care Among People with HIV — Implementation Technical Assistance Provider Apply for HRSA 25 058 Funding Number: HRSA 25 058 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Street Medicine Interventions for People with HIV who are Unsheltered – Capacity Builder Provider (HRSA-25-055) and Street Medicine Interventions for People with HIV who are Unsheltered – Evaluation Provider (HRSA-25-057) Apply for HRSA 25 057 Funding Number: HRSA 25 057 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
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