Opportunity Information: Apply for RFA AG 25 028
The NIH funding opportunity RFA-AG-25-028, titled "Mentored Career Enhancement Awards to Build Cross-Disciplinary Knowledge and Skills for Comparative Studies of Human and Nonhuman Primate Species with Differing Life Spans (K18 Clinical Trial Not Allowed)," supports experienced, already-independent investigators who want to significantly broaden their expertise into a new discipline so they can lead future research comparing why life spans differ across humans and nonhuman primate species. The central idea is career enhancement through mentored, cross-disciplinary training that meaningfully expands an investigator's scientific toolkit and network, positioning them to develop more integrative, comparative studies of primate aging and longevity.
This is a mentored career enhancement award (K18 mechanism) aimed at investigators who are established in one area but need structured training and mentorship to move into a substantially different field relevant to comparative primate research and aging. The program is explicitly designed to help investigators either augment or partially redirect their research program by building expertise outside their home discipline, and to stimulate new collaborations with research communities they do not typically engage. In practice, that means an applicant might be strong in one domain (for example, human aging epidemiology or molecular genetics) and propose a mentored plan to gain deep competence in another domain (for example, primatology, evolutionary biology, or comparative biology of aging), with the goal of integrating these approaches into future comparative studies of longevity.
The NOFO highlights several priority areas for cross-training and collaboration. These include comparative biology of aging, evolutionary genetics, evolutionary biology, anthropology, primatology, and human longevity studies. The emphasis is not on incremental skill-building within the applicant's current specialty, but on real cross-disciplinary movement into an area that is meaningfully different from their existing training and track record. The expectation is that, by the end of the award period, the investigator will be better prepared to lead comparative research programs examining biological, evolutionary, genetic, and environmental contributors to differences in life span across primate species, including humans.
Eligibility is geared toward senior investigators rather than early-career faculty. Applicants must hold the academic rank of associate professor or full professor, or an equivalent position in a non-academic research setting. Organizational eligibility is broad and includes many types of U.S.-based institutions and organizations, such as public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and multiple levels of government entities (state, county, city/township, and special district governments), as well as independent school districts and certain housing authorities. The opportunity also explicitly includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs), along with faith-based or community-based organizations and eligible federal agencies.
Foreign eligibility is restricted in a way that is typical for many NIH opportunities. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components, as defined by the NIH Grants Policy Statement, are allowed. In practical terms, the applicant institution must be U.S.-based, but the project can include certain forms of international collaboration or work conducted through an allowable foreign component when properly justified and compliant with NIH policy.
Administratively, the opportunity is offered by the National Institutes of Health, falls under the health funding activity category, and is associated with CFDA number 93.866. The listed original application due date is 2024-11-01. The NOFO is labeled "Clinical Trial Not Allowed," which means applicants should not propose a clinical trial as part of the K18 activities. The focus is on training, mentorship, and research career enhancement leading to comparative studies, rather than running interventional clinical trials under this award.
Overall, this K18 is meant to create a bridge for senior investigators to step outside their usual disciplinary lane, gain rigorous mentored training in another relevant field, and build durable cross-field collaborations. The expected payoff is a stronger pipeline of leaders capable of designing and directing sophisticated comparative studies across human and nonhuman primate species, ultimately advancing understanding of why life spans vary and what that can reveal about aging and longevity.Apply for RFA AG 25 028
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Mentored Career Enhancement Awards to Build Cross-Disciplinary Knowledge and Skills for Comparative Studies of Human and Nonhuman Primate Species with Differing Life Spans (K18 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2024-07-03.
- Applicants must submit their applications by 2024-11-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the NIH opportunity RFA-AG-25-028?
RFA-AG-25-028 is an NIH funding opportunity titled "Mentored Career Enhancement Awards to Build Cross-Disciplinary Knowledge and Skills for Comparative Studies of Human and Nonhuman Primate Species with Differing Life Spans (K18 Clinical Trial Not Allowed)." It supports mentored career enhancement for experienced, already-independent investigators who want to substantially broaden their expertise into a new discipline relevant to comparative studies of aging and longevity across humans and nonhuman primates.
What is the main goal of this K18 award?
The main goal is to help established investigators meaningfully expand into a substantially different field through mentored, cross-disciplinary training, so they are positioned to lead future comparative research on why life spans differ across primate species (including humans). The emphasis is on building new knowledge, skills, and collaborations that enable more integrative comparative studies of primate aging and longevity.
Who is this funding opportunity intended for?
This opportunity is geared toward senior, already-independent investigators rather than early-career faculty. Applicants must hold the academic rank of associate professor or full professor, or an equivalent position in a non-academic research setting.
What does "mentored career enhancement" mean in this context?
In this context, "mentored career enhancement" means the investigator proposes a structured plan of training and mentorship designed to build deep competence in a new discipline. The intent is not minor upskilling within the investigator's current specialty, but a significant cross-disciplinary expansion that meaningfully strengthens the investigator's scientific toolkit and professional network.
What kinds of cross-disciplinary moves does the NOFO encourage?
The NOFO encourages cross-disciplinary movement into areas that are meaningfully different from an applicant's existing training and track record. For example, an investigator rooted in human aging epidemiology or molecular genetics might seek mentored training in primatology, evolutionary biology, anthropology, evolutionary genetics, or comparative biology of aging, with the goal of integrating these approaches in future comparative longevity studies.
What research areas are highlighted as priorities for cross-training and collaboration?
The NOFO highlights priority areas including comparative biology of aging, evolutionary genetics, evolutionary biology, anthropology, primatology, and human longevity studies. The overall focus is comparative, cross-species understanding of aging and life span differences across humans and nonhuman primates.
Is this award meant to support incremental training within my current field?
No. The emphasis is explicitly not on incremental skill-building within the applicant's current specialty. The program is designed for real cross-disciplinary expansion into an area that is substantially different from the investigator's existing expertise.
What is the expected outcome by the end of the award period?
By the end of the award period, the investigator is expected to be better prepared to lead comparative research programs that examine biological, evolutionary, genetic, and environmental contributors to differences in life span across primate species, including humans. A key intended outcome is durable collaboration with research communities the investigator does not typically engage.
What does the K18 mechanism support in practice?
The K18 mechanism supports career enhancement through mentored training and structured cross-disciplinary development. It is intended to help investigators augment or partially redirect their research program by building expertise outside their home discipline and forming new collaborations that position them for future integrative comparative studies.
Are clinical trials allowed under this NOFO?
No. The NOFO is labeled "Clinical Trial Not Allowed," which means applicants should not propose a clinical trial as part of the K18 activities. The focus is on training, mentorship, and research career enhancement rather than conducting interventional clinical trials under this award.
When is the original application due date?
The listed original application due date is 2024-11-01.
What organization is offering this funding opportunity?
The opportunity is offered by the National Institutes of Health (NIH) and is associated with a health funding activity category.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.866.
What types of organizations are eligible to apply?
Organizational eligibility is broad and includes many types of U.S.-based institutions and organizations. Examples listed include public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and multiple levels of government entities (state, county, city/township, and special district governments), as well as independent school districts and certain housing authorities.
Are minority-serving institutions and community-based organizations included as eligible applicants?
Yes. The opportunity explicitly includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs). It also includes faith-based or community-based organizations and eligible federal agencies.
Can a foreign (non-U.S.) organization apply as the applicant institution?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply.
Are any international activities allowed if the applicant institution is U.S.-based?
Yes. While the applicant institution must be U.S.-based, foreign components (as defined by the NIH Grants Policy Statement) are allowed. In practice, this can allow certain forms of international collaboration or work conducted through an allowable foreign component when properly justified and compliant with NIH policy.
What is the scientific focus of the supported work?
The scientific focus is on building the capacity to conduct comparative studies that investigate why life spans differ across humans and nonhuman primate species. The goal is to strengthen integrative approaches that consider biological, evolutionary, genetic, and environmental contributors to primate aging and longevity.
Does the program aim to create new collaborations?
Yes. A central objective is to stimulate new collaborations with research communities the investigator does not typically engage, supporting cross-field networks that can sustain future comparative research programs.
Is this opportunity designed for investigators who are already independent?
Yes. The opportunity supports experienced, already-independent investigators and is framed as a way for established investigators to step outside their usual disciplinary lane through mentored training.
Does this award support a full career change or a partial redirection?
The program is designed to help investigators either augment or partially redirect their research program by building expertise outside their home discipline. The intent is to create a bridge into a new area relevant to comparative primate aging and longevity research.
What kinds of species comparisons are central to the program's aims?
The program centers on comparative studies across humans and nonhuman primate species with differing life spans, with the broader aim of understanding what life span variation can reveal about aging and longevity.
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